The song was co-written by Divinyls Australian vocalist Chrissy Amphlett who died of breast cancer five years ago aged 53.
“The music video is part of the I Touch Myself Project which was created in honor of celebrated diva, Chrissy Amphlett, who passed away from breast cancer, and who gave us her hit song to remind women to put their health first,” said the 23-time Grand Slam champion.
The video was viewed more than 1.3-million times in the first 10 hours after it was posted early on Sunday with fans lauding the tennis superstar for her bravery in performing the song.
“Amazing Serena, important message and such a beautiful voice!” wrote one under the username deedpaula.
Another alshaze47 commented: “This is powerful!! I’m a Breast cancer survivor!!”
The video appeared less than three weeks after her tempestuous US Open final defeat to Naomi Osaka, where Williams smashed a racquet and accused an umpire of sexism.
Williams, who celebrated her 37th birthday four days ago, pulled out of this week’s China Open in Beijing to bring a premature end to her 2018 season, her first back on tour since giving birth to a daughter a year ago.